Journal article
Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection
Z Wang, A Zhang, Y Wan, X Liu, C Qiu, X Xi, Y Ren, J Wang, Y Dong, M Bao, L Li, M Zhou, S Yuan, J Sun, Z Zhu, L Chen, Q Li, Z Zhang, X Zhang, S Lu Show all
Proceedings of the National Academy of Sciences of the United States of America | Published : 2014
Abstract
A unique avian-origin A/H7N9 influenza virus has so far caused134 cases with 44 deaths. Probing the host factors contributingto disease severity, we found that lower levels of plasma inflammatory cytokines on hospital admission correlated with faster recovery in 18 patients with A/H7N9 influenza virus, whereas highconcentrations of (in particular) IL-6, IL-8, and macrophage inflammatory protein-10 were predictive of a less favorable or fatal outcome. Analysis of bronchoalveolar lavage samples showed up to1,000-fold greater cytokine/chemokine levels relative to plasma.Furthermore, patients with the rs12252-C/C IFN-induced transmembrane protein-3 (IFITM3) genotype had more rapid diseaseprogres..
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Grants
Awarded by National Institute of General Medical Sciences
Funding Acknowledgements
This work was supported by the National Grand Program on Key Infectious Disease Control (Grants 2012ZX10001-006 and 2013ZX10001-002), China Ministry of Health; the 973 National Key Basic Research Project (Grant 2012CB519005), Ministry of Science and Technology of the People's Republic of China; and Australian National Health and Medical Research Council (NHMRC) Program Grant APP567122 (to P. C. D.). Z.W. is an NHMRC China-Australia Exchange Fellow, and K. K. is an NHMRC Career Development Fellowship Level 2 Fellow.